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5.1 Intervention strategies 5.1.1 Targeting iron homeostasis Iron chelators such as deferoxamine, deferiprone, and deferasirox bind free ferrous iron (Fe2+), reducing substrate availability for the Fenton reaction and thereby curtailing the lipid peroxidation cascade (152)
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Both peptides appear well tolerated in the limited settings studied, but long-term systemic human safety is uncharacterized for each, and research-grade material carries unverified identity and purity
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