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2A , 2 B and 2 C show (A) Urinary (B) Fecal elimination and (C) tissue retention respectively (expressed as percent of administered dose) of IV administered Co-60 in Fisher F344 rats: effect of repetitive treatment (once daily for 5 days) with ReadiSorb (oral) or non-formulated reduced glutathione (oral or IV)

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In one embodiment, sHASEGP is administered to a patient having a tumor associated with a LuCa-1 defect in an amount effective to increase diffusion around the tumor site (e.g., to increase circulation of chemotherapeutic factors (e.g., to facilitate circulation and/or concentrations of chemotherapeutic agents in and around the tumor site), inhibit tumor cell motility (e.g., by HA degradation) and/or to lower the tumor cell(s) threshold of apoptosis (i.e., bring the tumor cell(s) to a state of anoikis), a state that renders the tumor cell(s) more susceptible to the action of chemotherapeutic agents or other agents that may facilitate cell death, preferably preferentially facilitate programmed cell death of cells in anoikis

also known as ALCAR