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Knowing that SFN-NAC (SFN-N-Acetylcysteine) and SFN-Cys are important metabolites formed when SFN is metabolized through the mercapturic acid pathway, and using a molecular modeling approach, they discovered a plausible interaction for the carboxylate group of SFN-Cys within the active site of HDACs (histone deacetylases) using Zn as a bidentate ligand (Myzak et al
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