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Common Peptide Side Effects and Who Shouldn’t Take Them For the three licensed GLP-1 peptides, side effects are well-documented and largely gastrointestinal: Nausea - most common, usually in early weeks and after dose increases Constipation and diarrhoea Vomiting - more common with the oral pill form than injections Fatigue in early weeks Who should not take licensed GLP-1 peptides: History of medullary thyroid carcinoma or MEN2 syndrome Personal or family history of medullary thyroid cancer Pregnant or planning to conceive (stop at least 2 months before trying) Severe gastrointestinal disease For a full breakdown: most common side effects of GLP-1 agonists → Peptides to trust and the ones to avoid in the UK We’ve told you everything you need to know about the ones you should trust
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